HIGHLIGHTS
- who: Danuta Szczesna-Cordary from the La Trobe University, Australia have published the research: Functional comparison of phosphomimetic S15D and T160D mutants of myosin regulatory light chain exchanged in cardiac muscle preparations of HCM and WT mice, in the Journal: (JOURNAL) of November/30,/2023
- what: This approach has been previously tested in S15D phosphomimetic RLC-reconstituted cardiac preparations from HCM-D166V and HCM-R58Q mice, where S15D alleviated some of the detrimental HCM phenotypes in_vitro . The authors compared the T160 RLC site with the established S15-RLC site and performed a series of reconstitution . . .
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