HIGHLIGHTS
- who: Rafael I. Jaén and collaborators from the Instituto de Investigaciones Biomédicas Alberto Sols, CSIC-UAM, Madrid, Spain Departamento de Farmacología, Farmacognosia y Botánica, Facultad de Farmacia have published the Article: Functional Crosstalk between PCSK9 Internalization and Pro-Inflammatory Activation in Human Macrophages: Role of Reactive Oxygen Species Release, in the Journal: (JOURNAL)
- what: This work shows an additional mechanism of action of PCSK9 in Mϕ involving TLR4 activation, implicating the regulation of a plethora of responses, including lipid metabolism, inflammation, and apoptosis.
SUMMARY
Proprotein convertase subtilisin . . .
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