Functional dissection of n-terminal nuclear traf cking signals of setdb1

HIGHLIGHTS

• who: NES et al. from the United Kingdom Virginia Commonwealth University have published the paper: Functional dissection of N-terminal nuclear traf cking signals of SETDB1, in the Journal: (JOURNAL)
• what: The authors serially deleted the respective N-terminal motifs to investigate how each affected the nucleocytoplasmic movement of SETDB1. Based on the results of dissecting the N-terminal structure of SETDB1, the authors propose a model for nucleocytoplasmic trafficking of overexpressed SETDB1 in 293T_cells .
• how: The results showed that ATF7IP was nuclear only whereas SETDB1 was both nuclear and cytoplasmic in 293T . . .
  

   

  

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