Functional imaging of brain organoids using high-density microelectrode arrays

HIGHLIGHTS

• who: Manuel Schru00f6ter from the To probe single-cell and network activity of sliced hCOs and to identify neurons on the HD-MEA, we performed a series of activity scans, ie., sequential high-density recordings covering all electrodes of the array. To select recording electrodes, the multi-unit activity (MUA) for each electrode configuration was estimated using a sliding-window, threshold-crossing spike detection algorithm (detection threshold: , u00d7 the root mean square error of the noise of the bandpassfiltered signal). After the activity scan, and depending on the requirements of each analysis (single-cell or network-related . . .
  

   

  

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