HIGHLIGHTS
- who: TYPE and colleagues from the Department of New, Daegu-Gyeongbuk Institute of and (DGIST) have published the research: Functional implication of ubiquitinating and deubiquitinating mechanisms in TDP-43 proteinopathies, in the Journal: (JOURNAL)
- what: While ubiquitin-enriched cytoplasmic inclusion of TDP-43 is considered to be the proteopathic signature of ALS and FTD, the pathophysiological meaning of the ubiquitination has been a longstanding question.
SUMMARY
The CTD has been of great interest due to its intrinsic aggregation-prone property like the prion-like domain (King et_al, 2012) which apparently contributes . . .
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