Functional interdependence of the actin regulators cap1 and cofilin1 in control of dendritic spine morphology

HIGHLIGHTS

  • who: Anika Heinze from the Philipps-University of Marburg, Marburg, Germany have published the research work: Functional interdependence of the actin regulators CAP1 and cofilin1 in control of dendritic spine morphology, in the Journal: (JOURNAL)
  • what: The authors report spine enrichment of cyclase-associated 1 (CAP1) a conserved multidomain with largely unknown physiological functions. The authors report enrichment of CAP1 in the head of dendritic spines. The authors show that this depended on its helical folded domain (HFD), which is relevant for the interaction with cofilin1. The authors demonstrated important functions for CAP1 in postsynaptic . . .

     

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