HIGHLIGHTS
- who: Wei Lu and collaborators from the Department of Chemistry, University of Kentucky, Lexington, Kentucky, United States of America have published the research work: Functional Relevance of AcrB Trimerization in Pump Assembly and Substrate Binding, in the Journal: PLOS ONE | www.plosone.org of February/14,/2014
- what: The authors investigated the effects of each individual aspect, namely proton relay, interaction with AcrA/TolC, and trimerization, on substrate binding. The authors examined the relative accessibility of the substrate translocation pathway under three conditions: in AcrBDloop which is monomeric; in AcrBD407A which is defective in proton . . .
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