Functionally different agonists induce distinct conformations in the g protein coupling domain of the β2adrenergic receptor*

HIGHLIGHTS

• who: Pejman Ghanouni from the (UNIVERSITY) have published the research work: Functionally Different Agonists Induce Distinct Conformations in the G Protein Coupling Domain of the β2Adrenergic Receptor*, in the Journal: (JOURNAL)
• what: Based on the lifetime experiments, the authors propose a model with multiple, agonist-specific receptor states, wherein activation occurs through a sequence of conformational changes.

SUMMARY

Drugs that activate G protein-coupled receptors are classified as either agonists or partial agonists. When the ␤2 adrenergic receptor is bound to a full agonist, the G protein coupling domain exists in . . .

 



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