Fundamental immune-oncogenicity trade-offs define driver mutation fitness

HIGHLIGHTS

• who: David Hoyos from the (UNIVERSITY) have published the paper: Fundamental immune-oncogenicity trade-offs define driver mutation fitness, in the Journal: (JOURNAL) of 23/01/2021
• what: The authors propose a unified theoretical u2018free fitness` framework that parsimoniously integrates multimodal genomic, epigenetic, transcriptomic and proteomic data into a biophysical model of the rate-limiting processes underlying the fitness advantage conferred on cancer cells by driver gene mutations. The authors examine the relationship between oncogenicity and immunogenicity for tumour driver mutations, using p53 as a primary example, to develop a model for predicting therapeutic targeting . . .
  

   

  

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