HIGHLIGHTS
- who: Shuaifeng Li from the MOE Key LaboratoryZhejiang University Shenzhen, China have published the paper: FUNDC2 promotes liver tumorigenesis by inhibiting MFN1-mediated mitochondrial fusion, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: Due to the observation that FUNDC2 regulates mitochondrial dynamics, the authors focused on MFN1/2.
- how: To facilitate functional studies in_vivo the authors examined the expression of these genes in a mouse model of primary liver tumor generated by in situ genome editing of hepatocytes28-30. This result is in consistent with the accumulation of lipid droplets in FUNDC2 knockdown . . .
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