Fusion protein strategies for cryo-em study of g protein-coupled receptors

HIGHLIGHTS

• who: Kaihua Zhang from the (UNIVERSITY) have published the research work: Fusion protein strategies for cryo-EM study of G protein-coupled receptors, in the Journal: (JOURNAL) of 17/Dec/2021
• what: For this approach, the authors used mouse SMO (mSMO), another GPCR with previously determined crystal and cryo-EM structures. The authors demonstrate two alternative approaches to achieve such rigidity.
• how: The study shows that only one of the two can facilitate image alignment.

SUMMARY

In GPCR crystallography, inserting a fusion_protein between transmembrane helices 5 and 6 is . . .

 



If you want to have access to all the content you need to log in!

Thanks :)

Username or E-mail:

If you don't have an account, you can create one here.