Gβ residues that do not interact with gα underlie agonist-independent activity of k+ channels*

HIGHLIGHTS

• who: Tooraj Mirshahi from the (UNIVERSITY) have published the research work: Gβ Residues That Do Not Interact with Gα Underlie Agonist-independent Activity of K+ Channels*, in the Journal: (JOURNAL) of October/16,/2001

SUMMARY

Little is known about the identity of functionally important interactions between G␤␥ and GIRK channels. G␤1 and G␤5 both bind the N and C termini of the GIRK1 and GIRK4 channel subunits. Chimeric analysis between the G␤1 and G␤5 proteins revealed a 90-amino_acid stretch that spans blades two and three of the seven . . .

 



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