G protein-coupled receptor kinase phosphorylation of distal c-tail sites specifies βarrestin1-mediated signaling by chemokine receptor cxcr4

HIGHLIGHTS

• who: Ya Zhuo from the (UNIVERSITY) have published the research: G protein-coupled receptor kinase phosphorylation of distal C-tail sites specifies u03b2arrestin1-mediated signaling by chemokine receptor CXCR4, in the Journal: (JOURNAL) of February/10,/2022
• what: The authors provide evidence that distal carboxylterminal tail (C-tail), but not proximal, phosphorylation of the chemokine receptor CXCR4 specifies u03b2arrestin1 (u03b2arr1)dependent signaling. The authors demonstrate by pharmacologic inhibition of GRK2/3-mediated phosphorylation of the chemokine receptor CXCR4 coupled with site-directed_mutagenesis and bioluminescence resonance energy transfer approaches that distal, not proximal, C-tail phosphorylation . . .
  

   

  

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