HIGHLIGHTS
- who: Yutong Sui from the (UNIVERSITY) have published the research work: G-quadruplexes folding mediates downregulation of PBX1 expression in melanoma, in the Journal: (JOURNAL) of 24/02/2022
SUMMARY
Received Differently from G4s located 5` UTR of mRNA, which impede mRNA translation via steric blocking effects, G4s within promoter region regulate transcription by recruiting or blocking the occupancy of transcriptional factors in promoter regions. The authors next investigated the transcriptional factors involved in the regulation of dG1 on PBX1 transcription. By using transcriptional factors prediction software PROMO, nine transcriptional factors were predicted . . .
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