HIGHLIGHTS
- who: Conghui Li from the School of Basic Medical, University, China have published the paper: G-quadruplexes sense natural porphyrin metabolites for regulation of gene transcription and chromatin landscapes, in the Journal: (JOURNAL)
- what: The authors characterized natural porphyrins PpIX and hemin in cells with mass spectrometry and confirmed their direct interactions with G4 by bio-layer interferometry (BLI). The studies propose that hemin regulates gene_expression through two distinct mechanisms depending on the involvement of G-quadruplexes (Fig 7H). The authors propose that G4 status can function as a sensor for hemin in the genome . . .
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