G2 checkpoint targeting via wee1 inhibition radiosensitizes egfrviii-positive glioblastoma cells

HIGHLIGHTS

• who: Meryem H. Cetin from the Department of Radiobiology and, University Medical Center Hamburg-Eppendorf, Martinistr52, Hamburg, Germany have published the paper: G2 checkpoint targeting via Wee1 inhibition radiosensitizes EGFRvIII-positive glioblastoma cells, in the Journal: (JOURNAL)
• what: The aim of this study was therefore to investigate whether isogenic EGFRvIII-/+ cell lines can be radiosensitized by the clinically relevant Wee1 inhibitor adavosertib. The authors show that Wee1 inhibition can effectively radiosensitize both, EGFRvIII- and EGFRvIII+ GBM cells (Fig 4B). The authors used inhibitor concentrations, which had been demonstrated to be achievable in the brain respectively . . .
  

   

  

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