G2e3 is a dual function ubiquitin ligase required for early embryonic development*

HIGHLIGHTS

• who: William S. Brooks from the (UNIVERSITY) have published the research work: G2E3 Is a Dual Function Ubiquitin Ligase Required for Early Embryonic Development*, in the Journal: (JOURNAL) of April/28,/2008
• what: The authors characterize the cell cycle-regulated ubiquitin ligase known as G2E3, demonstrating its biochemical function, physiologic function, and its in_vivo expression pattern.

SUMMARY

G2E3 has a C-terminal HECT (homologous to E6-associated protein C terminus) domain, a motif that typically functions in ubiquitination. There are three N-terminal zinc_finger domains with varying similarity to both RING . . .

 



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