G4-quadruplex-binding proteins: review and insights into selectivity

HIGHLIGHTS

  • who: Vanessa Meier-Stephenson from the Department of Medicine, Division of Infectious Diseases, University of Alberta, Edmonton, AB, Canada have published the article: G4-quadruplex-binding proteins: review and insights into selectivity, in the Journal: (JOURNAL)
  • what: This work provides the authors with some of the first supporting data for how this class of proteins may in fact interact with these structures.
  • how: Their results showed that any one finger of Gq1 could be replaced with the corresponding finger of Zif268 without losing quadruplex affinity or duplex discrimination but when two fingers were . . .

     

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