Gabaergic synaptic scaling is triggered by changes in spiking activity rather than ampa receptor activation

HIGHLIGHTS

• What: The authors show results that GABAergic scaling can act to homeostatically control spiking levels. The authors propose that GABAergic scaling rather than glutamatergic scaling is a key player in spike rate homeostasis. 1 of 31 __NEWPAGE__eLife assessment This study assesses homeostatic plasticity mechanisms driven by inhibitory GABAergic synapses in cultured cortical neurons. In Figure 2B the authors show that TTX-induced scaling does produce a largely multiplicative downscaling with a scaling factor of slightly less than 0.5.
• Who: Neuroscience and collaborators from the Department of Cell BiologyEmory University, School of Medicine, Atlanta, GA . . .
  

   

  

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