Gabp couples oncogene signaling to telomere regulation in tert promoter mutant cancer

HIGHLIGHTS

• who: Andrew M. McKinney from the University of California, San Francisco, San Francisco, CA, USA have published the research: GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer, in the Journal: (JOURNAL) of September/20,/2022
• what: The authors demonstrate that proliferation arrest decreases expression a GABP-dependent manner and elucidate a critical proliferation-to-immortality pathway from EGFR to expression selectively from the mutant TERTp through activation of AMP-mediated kinase (AMPK) and upregulation. The authors demonstrate that the effects of EGFR on GABP-TERTp regulation can be partially attributed to . . .
  

   

  

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