Gain-of-function mutation w493r in the epithelial sodium channel allosterically reconfigures intersubunit coupling*⒦

HIGHLIGHTS

• who: Mahmoud Shobair from the (UNIVERSITY) have published the article: Gain-of-Function Mutation W493R in the Epithelial Sodium Channel Allosterically Reconfigures Intersubunit Coupling*⒦, in the Journal: (JOURNAL) of February/19,/2016
• what: The authors propose a structural model of activation of the epithelial sodium channel by the pathological gain-of-function mutation ␣W493R.
• future: Models of oligomeric interfaces are grouped into clusters by two geometric metrics the direction of axis of symmetry and the projection of center of mass of the asymmetric unit on the axis of symmetry.

SUMMARY

 



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