HIGHLIGHTS
- who: Yingying Chen et al. from the Guangzhou Laboratory Sciences, Guangzhou, China have published the Article: Gain-of-function mutations in Trim71 linked to congenital hydrocephalus, in the Journal: (JOURNAL)
- how: This result was in line with published findings using mouse embryos (Trim71-KO and a CH-associated mutant) that highlighted the important role of Trim71 in neurogenesis .
SUMMARY
A new study in PLOS Biology reports a potential gain-of-function pathological mechanism of congenital hydrocephalus in mouse embryonic stem_cells that involves Wnt-β-catenin signaling pathway regulation. Hydrocephalus, one of the . . .
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