HIGHLIGHTS
SUMMARY
Prodrug design is a well-known strategy that consists of chemically modifying the structure of a drug, which is called the "parent drug". In the former, the molecule acts as a substrate for enzymes, which then release the active drug, whereas, in the latter, the parent drug is linked through enzymatically or chemically cleavable groups to a molecule that acts as a carrier. The use of galactosylated prodrugs has proven to be an excellent strategy, particularly when parent drugs are likely to fail therapeutically due to a lack of site-of-action specificity, a . . .
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