Gasdermin d-deficient mice are hypersensitive to acute kidney injury

HIGHLIGHTS

• who: Wulf Tonnus from the (UNIVERSITY) have published the research: Gasdermin D-deficient mice are hypersensitive to acute kidney injury, in the Journal: (JOURNAL) of 30/08/2022
• what: The authors demonstrate a unique peritubular pattern of GSDMD expression during AKI and show GSDMD-deficient mice to be hypersensitive to IRI and cisplatin-induced AKI. The authors demonstrate the first evidence of pyroptosis and necroptosis to function in different cell types during AKI to prevent further deterioration and propagation of tubular damage.
• how: The authors investigated Gsdmd- Gsdme- and double-deficient mice in . . .
  

   

  

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