Gasdermin e deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation

HIGHLIGHTS

• who: Weiwei Xia from the Institute of Biological SciencesTo construct the cisplatininduced AKI animal model, the GSDME-/-(KO), GSDME-/+ (HET) mice, and their WT littermates (12week-old, male mice) were randomly divided into six groups: WT+ Saline: n=5, HET+ Saline: n=5, KO+ Saline: n=5, WT+ Cisplatin: n=7, HET+ Cisplatin: n=7, and KO+ Cisplatin: n=7. A single dose of cisplatin (, mg/kg, Sigma-Aldrich, MO, USA) or the same volume of saline was intraperitoneally injected into the WT, HET, and KO mice. Experimental mice were sacrificed after , h of cisplatin injection. To . . .
  

   

  

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