HIGHLIGHTS
SUMMARY
Since plasma LD concentrations are strongly linked with drug effects, it is important to better investigate the LD pharmacokinetics (PK) to improve the drug efficacy and safety. The latter is one of the most important factors since women are more prone to develop LD-related complications compared with men. Women show higher LD bioavailability than men as assessed by higher values of the AUC and maximum plasma concentration (Cmax). No previous study has investigated factors possibly influencing plasma LD concentrations and PK parameters in female and male patients with PD assuming LD for the . . .
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