HIGHLIGHTS
- who: Qi Wang from the (UNIVERSITY) have published the research work: Gene body methylation in cancer: molecular mechanisms and clinical applications, in the Journal: (JOURNAL)
- future: Studies are needed to investigate the mechanism of how demethylation induces tumour dedifferentiation. The relationship and interaction mechanism between the two have not been elucidated and further experimental studies are still needed.
SUMMARY
In the 1970s, Riggs AD and Holliday R proposed that methylation of the 5′-terminal cytosine (5′-C) of CpG dinucleotides is an important epigenetic marker of gene silencing that can cause . . .
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