HIGHLIGHTS
- who: Jessica A. Kretzmann from the (UNIVERSITY) have published the research: Gene-encoding DNA origami for mammalian cell expression, in the Journal: (JOURNAL) of 24/Oct/2022
- what: The authors demonstrate enhanced gene_expression efficiency by including and tuning multiple functional sequences and structures, including virus-inspired inverted-terminal repeat-like (ITR) hairpin motifs upstream or flanking the expression cassette. The work provides a framework for exploiting DNA origami for gene delivery applications. The authors investigate the determinants for designing the sequences of synthetic DNA origami scaffolds and the structures of DNA origami objects, so that . . .
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