HIGHLIGHTS
SUMMARY
One such factor contributing to disease risk is an individual`s genetics, with some individuals inheriting specific genetic variants that either directly trigger disease pathogenesis or work in concert with other factors and/or other genetic variants to increase disease risk. Such variants likely alter gene regulatory mechanisms, leading to genotype-dependent variability in gene_expression levels that contribute to disease risk, often by altering transcriptional elements (e_g, promoters or distal regulatory elements such as enhancers) or posttranscriptional elements (e_g, regions controlling mRNA_splicing or mRNA localization). To increasing disease risk through interaction with human regulatory . . .
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