Gene inversion and duplication cause no obvious hemophilia a phenotype

HIGHLIGHTS

  • who: . et al. from the Zhejiang University, China have published the Article: gene inversion and duplication cause no obvious hemophilia A phenotype, in the Journal: (JOURNAL)

SUMMARY

    F8 gene locates at the end of the long arm of X chromosome (Xq28), including 25 introns and 26 exons, with a total length of about 186 kb (Gitschier et_al, 1984; Freije and Schlessinger, 1992). Intron 22 contains a 9.5-kb sequence Int22h-1, which is about 5.78 kb downstream of exon 22, and there are two homologous repeats (Int22h-2 and Int22h-3 . . .

     

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