Gene networks and pathways for plasma lipid traits via multitissue multiomics systems analysis

HIGHLIGHTS

  • who: Montgomery Blencowe from the DepartmentUniversity of Angeles, CA, USA have published the Article: Gene networks and pathways for plasma lipid traits via multitissue multiomics systems analysis, in the Journal: (JOURNAL)
  • what: The authors utilized an integrative genomics approach leveraging diverse genomic data from human populations to investigate whether genetic variants associated with various plasma lipid traits, namely, total cholesterol, high and low density lipoprotein cholesterol (HDL and LDL), and triglycerides, from GWASs were concentrated on specific parts of tissue-specific gene_regulatory_networks. Experimental validation of F2 KD subnetworks in 3T3-L1 and C3H10T1/2 adipocytes . . .

     

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