Gene targeting to the cerebral cortex following intranasal administration of polyplexes

HIGHLIGHTS

• who: Asya I. Petkova and collaborators from the UCL School of Pharmacy, Brunswick Square, London WC N AX, UK have published the article: Gene Targeting to the Cerebral Cortex Following Intranasal Administration of Polyplexes, in the Journal: Pharmaceutics 2022, 14, 1136. of 18/03/2022
• what: The authors report gene delivery to the using a glycol chitosan-DNA polyplex (GCP). While others have reported delivery to multiple brain regions upon nasal administration, the authors aimed to achieve targeted delivery to the cortex to exploit the clinical potential for developing effective gene therapies against Alzheimer`s . . .
  

   

  

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