HIGHLIGHTS
- who: Yexuan Deng from the (UNIVERSITY) have published the Article: Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance, in the Journal: (JOURNAL) of 29/08/2021
- what: The authors show the potential of the CRISPRa model for mimicking disease and providing insights into resistance mechanisms towards targeted therapies. 3 WT mice and 4 dCas9a-SAMKI/KI mice were used for the analysis showing similar results. This analysis showed no major differences in the transcriptional expression profile between the WT and dCas9aSAMKI/+/sgNT expressing cells. The authors . . .
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