Generation of gαi knock-out hek293 cells illuminates gαi-coupling diversity of gpcrs

HIGHLIGHTS

• who: Yuki Ono from the Tohoku University have published the research work: Generation of Gu03b1i knock-out HEK293 cells illuminates Gu03b1i-coupling diversity of GPCRs, in the Journal: (JOURNAL) of 11/01/2023
• how: To compare Gu03b1i-subunit-coupling selectivity across receptors in a uniform way the authors calculated a parameter known as relative intrinsic activity (RAi)28. Data availability All data generated or analyzed in study are provided in the Supplementary Data 1.
• future: Since signaling properties of GPCRs are also dependent on Gu03b1 expression profiles of the cells and their localization . . .
  

   

  

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