Generation of tumor antigen-specific ipsc-derived thymic emigrants using a 3d thymic culture system

HIGHLIGHTS

• who: Raul Vizcardo from the NIH, Bethesda, MD, USA State University have published the research work: Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System, in the Journal: (JOURNAL) of March/20,/2018
• what: The authors demonstrate that iTEs are a homogeneous population of tumor antigen-specific post-thymic T_cells with similarities to naive T_cells.
• how: The results indicated that extrathymic T_cells differentiated using the current OP9/DLL1 system exhibit a developmental divergence from endogenous T_cells during the DP-to CD8aSP-transition. The results indicated that extrathymic . . .
  

   

  

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