Genetic alterations during the neoplastic cascade towards cholangiocarcinoma in primary sclerosing cholangitis

HIGHLIGHTS

• who: J Pathol and collaborators from the Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands have published the paper: Genetic alterations during the neoplastic cascade towards cholangiocarcinoma in primary sclerosing cholangitis, in the Journal: (JOURNAL)
• what: The authors aimed to assess the genetic alterations during progression of the neoplastic cascade from biliary dysplasia towards CCA in PSC. In the study , several regions per specimen were investigated to avoid the risk of missing alterations due to intratumor molecular heterogeneity . To these known mutations in PSC-CCA, the assessment of a . . .
  

   

  

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