HIGHLIGHTS
SUMMARY
Bile is an aqueous solution and contains three major lipids such as cholesterol, phospholipids, and bile acids, with bile pigments being a minor solute. By weight, bile acids make up about two thirds of the solute mass in normal human bile and are a family of closely related acidic sterols 2 of 25 that are synthesized from cholesterol in the liver through two pathways, i.e., the classical or neutral and the alternative or acidic pathways. As bile is gradually concentrated in the biliary tree from the bile canaliculi to intrahepatic bile ducts, then . . .
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