Genetic architecture of self-limited delayed puberty and congenital hypogonadotropic hypogonadism

HIGHLIGHTS

  • who: Valeria Vezzoli and collaborators from the University of Campania Luigi Vanvitelli, Italy have published the article: Genetic architecture of self-limited delayed puberty and congenital hypogonadotropic hypogonadism, in the Journal: (JOURNAL)
  • what: The results of this work show a fair correlation between patient genotype and clinical diagnosis, with a specificity of 100% and PPV of genetic tests for the diagnosis of patients with CHH.
  • future: Hormonal responsiveness to kisspeptin in boys with delayed puberty appears to be a promising new hormonal marker although currently further studies are needed . particularly the bilateral form . . .

     

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