Genetic evidence for the involvement of mismatch repair proteins, pms2 and mlh3, in a late step of homologous recombination

HIGHLIGHTS

• who: Md Maminur Rahman from the (UNIVERSITY) have published the research work: Genetic evidence for the involvement of mismatch repair proteins, PMS2 and MLH3, in a late step of homologous recombination, in the Journal: (JOURNAL) of March/19,/2020
• what: Taken together, the authors propose that MLH3 and PMS2 promote HR as endonucleases, most likely by processing JMs in mammalian somatic_cells. recognition of mismatches by the heterodimers MSH2-MSH6 (MutSa) and MSH2-MSH3 (MutSb) . This study shows compelling genetic evidence for the requirement of the PMS2 and MLH3 endonuclease activity for the efficient resolution of . . .
  

   

  

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