Genetic requirement of dact1/2 to regulate noncanonical wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis

HIGHLIGHTS

• What: The authors aimed to examine the genetic interactions between dact1/dact2 and key Wnt regulators such as wnt11f2, gpc4 and wls. The authors aimed to investigate the relationship of this defect to the midfacial dysmorphism of the dact1/2 mutant. The authors focused on these cell types because they contribute significantly to convergent extension processes and axis establishment. The authors examined how dact1 and dact2 interact with Wnt signaling during early embryogenesis and craniofacial morphogenesis.
• Who: Shannon H. Carroll and collaborators from the Center for Craniofacial Innovation, Children`s Hospital of Research Institute, Children . . .
  

   

  

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