HIGHLIGHTS
- who: Short Communication and collaborators from the University of California San Diego, Department of Pediatrics, La Jolla, CA, USA have published the Article: Genetics and Molecular Biology, in the Journal: (JOURNAL)
- how: Previous data showed that neuronal progenitor cells (NPCs) support L1 retrotransposition during neuronal differentiation in_vitro and in_vivo resulting in a L1 genetic mosaic nervous system (Muotri et_al 2005 Muotri 2016 Macia et_al 2017). While the data was observed using an ectopic L1 reporter construct it is currently unknown if these other interchromosomal translocations were caused by endogenous L1 retrotransposition.
SUMMARY
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