Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer

HIGHLIGHTS

• who: Zhi Hu from the Research UK, Cambridge Institute, Cambridge, UK and Science University, SW Bond Ave, CH B, Portland, OR, USA have published the article: Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer, in the Journal: (JOURNAL)
• what: The authors show that co-amplification of transcription factors that putatively target mitotic apparatus network genes is strongly associated with increased transcriptional activity of the mitotic apparatus network.
• how: As germline polymorphisms associated with aspects of cancer genesis and/ or progression . . .
  

   

  

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