HIGHLIGHTS
- who: Edubiel A. Alpizar-Sosa from the University of London, United Kingdom have published the paper: Genome deletions to overcome the directed loss of gene function in Leishmania, in the Journal: (JOURNAL)
SUMMARY
LmjF.13.1530 is annotated as a phospholipid transporting ATPase 1-like protein and is known to encode the miltefosine transporter (MT) where multiple studies have demonstrated that its mutation or loss leads to resistance to miltefosine through diminished drug uptake (Seifert et_al, 2003; Zhang and Matlashewski, 2015; Espada et_al, 2021). LmxLCB2 (LmxM.34.0320) knockout failed using the same . . .
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