Genome-wide association meta-analysis of childhood and adolescent internalizing symptoms

HIGHLIGHTS

• who: Eshim S. Jami MSc from the increase power to detect genome-wide significant lociThis expectation was based on the reasonably strong correlations between measurements from different raters or at different ages. Instead, the burden of heterogeneity within childhood measurements amplified noise in the dataset. Combined with sample size limitations, this resulted in reduced statistical power, which is reflected in the low SNP heritability and lack of genome-wide significant findings. Second, the low estimate of SNP heritability in this study can also partly be explained by the methods: estimates of SNP heritability from summary statistics are . . .
  

   

  

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