HIGHLIGHTS
- who: Paul A Lyons from the (UNIVERSITY) have published the research work: Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: This analysis provides robust evidence of a differential genetic basis of MPO+ and ANCA-negative EGPA at the HLA-DQ region. This study has identified 11 loci associated with EGPA, and reveals genetic and clinical differences between the MPO+ EGPA subset, and the larger ANCA-negative subset (with PR3+ ANCA patients too rare to be informative). The Republic of . . .
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