Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases

HIGHLIGHTS

• who: J Cobb from the Study population A cohort of children was recruited for the SPARKS-CHARM (CHildhood Arthritis Response to Medication) Study, which has the overall aim to improve understanding of the variability in response to treatment observed in children with JIA and ultimately define a multifactorial model of response outcomes [14] and through the CHARMS-JIA GWAS International ConsortiumAll cases fulfilled the International League of Associations for Rheumatology (ILAR) criteria for JIA and were about to start new MTX treatment for active arthritis [14]. The study had full ethical approval and was fully compliant with . . .
  

   

  

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