Genome-wide profiling of 5-hydroxymethylcytosines in circulating cell-free dna reveals population-specific pathways in the development of multiple myeloma

HIGHLIGHTS

• who: Brian C.-H. Chiu from the disparities [1]Although the importance of epigenetics to MM is recognized, previous studies have not investigated genome-wide, hydroxymethylcytosines (5hmC), a cytosine modification with a distinct genomic distribution and regulatory role from the more-investigated, methylcytosines (5mC) [2]. Reduced global, hmC levels have been found in MM [3] and MM-specific hydroxymethylome is associated with cell proliferation and prognosis [4]. To improve understanding of the role of, hmC in disparities in MM, we conducted a genome-wide, hmC profiling using the, hmC-Seal and the next-generation sequencing in circulating . . .
  

   

  

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