Genomic alk alterations in primary and relapsed neuroblastoma

HIGHLIGHTS

  • who: Carolina Rosswog from the DepartmentUniversity Children Cologne, Cologne, Germany have published the research work: Genomic ALK alterations in primary and relapsed neuroblastoma, in the Journal: (JOURNAL)
  • what: Tumor specimens were investigated for the purpose of this study in the lab of experimental pediatric oncology in Cologne to validate ALK alterations found previously and to understand their dynamics over the course of disease.
  • how: The following genes and gene regions were evaluated for mutations ALK (Exons 21-25) AKT1 (Exon 4) BRAF (Exons 11 and 15) CTNNB1 (Exon 3) DDR2 (Exons 3-18 . . .

     

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