HIGHLIGHTS
- who: Fereshteh Izadi and colleagues from the School of Cancer Sciences, Cancer Research UK Centre, Faculty of Medicine, University of Southampton have published the Article: Genomic Analysis of Response to Neoadjuvant Chemotherapy in Esophageal Adenocarcinoma, in the Journal: (JOURNAL)
- what: The authors report a higher non-synonymous mutation burden in responders (median 2.08/Mb vs. 1.70/Mb p = 0.036) and elevated copy number unique to each group in the cohort with cell cycle (CDKN2A CCND1) c-Myc (MYC) RTK/PIK3 (KRAS EGFR) and gastrointestinal differentiation (GATA6) pathway genes being specifically altered in . . .
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