HIGHLIGHTS
- who: Jin Sun Lee and colleagues from the Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Center have published the research work: Genomic Markers of CDK 4/6 Inhibitor Resistance in Hormone Receptor Positive Metastatic Breast Cancer, in the Journal: Cancers 2022, 14, 3159. of /2022/
- what: In the current study, despite the limited sample size and the low frequency of many somatic mutations, several statistically significant patterns were identified, including genomic alterations associated with CDK4/6i resistance: FGFR1 amp, ZNF703 amp, CDK4 amp, PALB2 mut, BRCA1 mut, RB1 loss, CDKN2B loss . . .
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